Drees has served in multiple regional and national roles in education, including the Liaison Committee on Medical Education, Chair of the Governance Council of the American Medical Associations Academic Physician Section, and Chair of the Missouri State Medical Associations Commission on Continuing Medical Education. SN 10 Science News names SaraH in list of top ten scientists to watch in 2020. Halfmann joined the Institute in 2015 as an Assistant Investigator. Brian Slaughter, Ph.D., is the Senior Director of Research Support at the Stowers institute, appointed in March 2022. Using advanced imaging and genetic techniques, hes untangling the mechanisms by which human cells activate proteins to block invaders. This cleanup process, called mitophagy, can malfunction in people with Alzheimers, Parkinsons, and other neurodegenerative diseases. In 1996, he was appointed an Associate Member of Whitehead and assistant professor of biology at MIT. Haglers research will bridge the gap between traditional biochemistry and high-throughput genomics to build a predictive model based on biophysical data. Support your mental health and your emotional and spiritual needs. The Graduate School of the Stowers Institute, B.S.,Biology and General Studio Art, University of Miami, Coral GablesPh.D.,Molecular andCellular Biology, Stony Brook University. Weakening these walls could one day form the basis of new antibiotics, a development that could thwart antimicrobial resistance. Genetics and Genomics, She plans to determine the specific mutations that help these proteins resist attack. Individual awards are available to scholars from over 100 countries. In 2021, HHMI expanded our commitment to advance inclusion at key career stages in academic science. Farmer thinks birth defects like craniosynostosis, when the bones of a babys skull fuse prematurely, might result from an inability to maintain stem cells in the long-term. Contact. Julia Zeitlinger, Ph.D., is a developmental and computational biologist where she serves as an Investigator at the Stowers Institute. By tracing how a cuttlefishs nerve cells translate visual information into instructions for color-changing structures in their skin, she plans to explore how the brain creates internal images of the outside world. The CRISPR-based technology will help scientists unravel the tapestry of interactions within complex biological networks. Scientists often rely on mice to probe neurodegenerative diseases. Sofia Quinodoz is unpacking the organization of cells nuclei. Leveraging our immune system to fight tumors is becoming a frontline therapy for cancer treatments. Help you and your family with difficult medical decisions. Congratulations to Fibo for earning a spotlight in eLife's Digest for his use of mathmatical modelling to study wtf drivers. Then, hell create a computational model that can predict those properties from a proteins structural code. Biological cells from bacteria to those in our bodies maintain a difference in voltage, called membrane potential, between their exterior and interior. The BioMedCAS 2022-2023 application cycle is now open to create an account. Jinelle Wint, Ph.D., is the Assistant Dean for Academic Affairs for the Graduate School of the Stowers Institute for Medical Research. Theyre constantly sending different sets of proteins to different parts of the cell and delivery mix-ups can be disastrous. The Hanna H. Gray Fellows Program honors the contributions of Hanna Holborn Gray, PhD, over her 28 years of service as a trustee of HHMI. The 2022 Stowers Report celebrates some of the incredible contributions our scientists, students, and staff have achieved this past year, including collaborations, science, and innovations that contribute to our better understanding of the secrets underlying fundamental biological processes. David Martinez is examining the quirks of the human immune system that make our antibody responses to dengue virus infection so different from the defenses mounted against its cousins, which include Zika virus, yellow fever virus, and West Nile virus. Genomic and Computational Approaches to Understanding Gene Expression. He joined Stowers in 2015. Bartel is now a Howard Hughes Medical Institute Investigator, a Member at Whitehead, and professor at MIT. Nuez plans to identify and examine the function of mysterious molecules called long non-coding RNAs, which can promote the growth of cancer cells and stem cells. Robb Krumlauf, Ph.D., a world-renowned developmental biologist, joined the Stowers Institute in 2000 as the first Scientific Director and Investigator. Bravo Nez is investigating whether genes that play a role in creating sperm and egg cells, if turned on under the wrong conditions, can create aneuploid cells, and whether these cells may offer genetic advantages by increasing resistance to stressors. Shes studying rats and mice to learn how their brains can solve similar problems and produce comparable behaviors. Her work may lead to new ways to prevent disease progression and suggest novel strategies to control infection. Kyle Card is using bacteria from various stages of the seminal E. coli long-term evolution experiment (LTEE) which has tracked bacterial evolution over more than 70,000 generations to examine how bacterias evolutionary history, together with population size and mutation rates, contribute to the evolution of antibiotic resistance and associated fitness costs. During her tenure, the Institute made significant changes to its process for selecting the scientists in which it invests, opening its doors to an ever-increasing pool of applicants. Following herfellowship, she did postdoctoral research training in the Veterans Affairs Career Development Program. We are not currently accepting applications. Evolutionary Biology, As part of the Diploma program in Meteorology at the . Jennifer Gerton, Ph.D., is a molecular and cellular biologist focusing on chromosome dynamics and behavior during cell division. Through their successful careers, HHMI Hanna Gray Fellows will become leaders in academic research who inspire, train, and mentor future generations of scientists. . 22 years 9 months Investigator, Scientific Director Emeritus Jul 2019 - Present4 years 1 month Kansas City, Missouri Area Scientific Director Nov 2000 - Jun 201918 years 8 months Head of Division. Gene Expression: Transcription to Translation; Genomic and Computational Approaches to Understanding Gene Expression; Laboratory Rotation; Thesis Laboratory. Andrea Cuentas-Condoris research aims to understand how some neurons communicate using two different neurotransmitters rather than one. She has characterized key regulators of a signaling pathway that tells cells to grow, a process that goes awry in cancer and diabetes. HHMI Hanna Gray Fellow / 2022-Present Stowers Institute for Medical Research. Pimentel is interested in how peoples genetic variation affects RNA splicing how cells edit RNA copies of genes. Reyes Ruiz will detail how staph bacteria respond to the mineral manganese, and then work out the mechanisms by which immune cells starve bacteria of manganese to fight back. Hua Li joined the Stowers Institute in 2006 and completed her postdoctoral training in 2007. To transition to the faculty phase of the program, fellows must obtain a tenure-track (or equivalent) faculty position at a U.S. (including Puerto Rico) research institution with a doctoral-level graduate program in their area of interest. Steve Bonilla is using cryogenic electron microscopy, known as cryo-EM, to visualize diverse, dynamic, functional RNA structures. The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. This high-resolution method promises to reveal a complex and dynamic atlas of neurotransmitters in the brain. Medina hopes to uncover the molecular mechanisms underlying these traits in chytrids, which could aid efforts to fight fungal pathogens. At the Howard Hughes Medical Institute, we believe in the power of individuals to advance science through research and science education, making discoveries that benefit humanity. Intrigued by the molecular underpinnings of life, Jay Unruh pursued a B.S. In this role, Slaughter oversees the various Technology Centers, including Microscopy, Sequencing, Proteomics, and Model Research Organisms, teaming with the Scientific Director and the Chief Scientific Director to direct the technology focus of the Institute. The office is closed for lunch from 12:00 - 1:00 p.m. every day. Using the genetic tool CRISPR to turn down the activity of specific genes and see what changes occur, Jinich hopes to identify and characterize hundreds of unknown enzymes, revealing new drug targets. So long as humans use antibiotics to fight bacteria, antibiotic resistance will be with us. As a doctoral student, Quinodoz developed a new way to map how the nucleus is organized. Copyright Stowers Institute for Medical Research https://www.stowers.org Using retinal organoids retinal tissue cultures derived from human stem cells as a model system, Eldred seeks to understand the factors that help generate important cell types in the retina, as well as the factors that divert cells down an unplanned path toward tumorigenesis. Chytrids are unique among fungi because they share certain traits with animals that have been lost in other fungi over time, including cells that swim in a similar fashion to animal sperm cells. This project provides outreach to primary care providers to meet professional development needs. B.S., Computer Science, University of Kansas. Mentors: Harmit S. Malik, PhD, and Arvind Rasi Subramaniam, PhD. Within our cells, proteins are routinely modified by post-translational modifications that grow the diversity and function of the approximately 20,000 proteins encoded by the human genome. Halleh Balch is a physicist pioneering new technologies deployed on autonomous underwater vehicles (AUVs) to study oceanic microorganisms and their impact on climate and human health. Autumn Holmes is examining how chikungunya virus, which causes debilitating, often chronic arthritis in humans, enters cells and begins the infection process in mice. His lab focuses on mammalian olfactory systems involved in perception and behavior. Thiago Monteiro Arajo dos Santos finds the invisible world of microbes captivating. When people infected with dengue virus later become infected with a second variant of the virus, they can experience severe, sometimes hemorrhagic reactions. Insects with certain parasitic fungal infections end their lives like zombies, somehow compelled to climb to a high point before spores explode from their bodies. Just a few kinds of signals control the fates of cells that either maintain their stem cell state, divide or differentiate in a developing organism. Giancarlo Bruni seeks to understand how evolution has shaped membrane potential within and across species, and how differences in membrane potential contribute to biological variation between individuals. Jessica Warren is investigating how the chloroplasts bacterial structures and genetic features have been integrated into modern plant cells, and how this incorporation controls plant development and physiology. Probiotics can populate the gut with a bevy of beneficial bacteria but to be effective, those supplemental microbes need to stick around and multiply, not pass right through. Each fellow participates in professional development, mentorship, and networking with their community of peers and the broader HHMI community of scientists across career stages. She hopes her work will reveal how we learn to predict foods effect on the body and guide development of therapies for metabolic disease. Molecular and Cell Biology, Better drugs require new targets, such as enzymes crucial to the bacterias survival that arent found in humans. Working in yeast, Phillips is hunting for patterns in this variability. These granules are thought to slow down cells protein-making machinery and may be tied to disease but their exact role is unknown. Cellular stresses, such as those caused by infection or chronic disease, trigger a general shutdown of protein synthesis. A Kansas City native, Smith trained as an artist before earning her B.S. Wint received her Ph.D. in molecular and cellular biology from Stony Brook University in the laboratory ofHoward Sirotkin, Ph.D. She has a bachelors degree in biology and general studio art from the University of Miami in Coral Gables, Florida. By studying healthy nerve cells and cells from people with neurodegenerative diseases, Evans plans to find out how nerve cells perform this important quality control, and how the process might be corrected when something goes wrong. Were always interested in finding motivated researchers to join the lab. Ngoc-Han Tran studies the endoplasmic reticulum a cellular compartment that varies in size and shape and performs a wide range of essential functions throughout its dynamic partitioning in the ovary. Madelaine Gogol is a Manager in the Computational Biology Core Facility at the Stowers Institute for Medical Research. Molecular and Cell Biology, HHMI empowers exceptional scientists and students to pursue fundamental questions in basic science. Program Academics Foundational research is the essence of our program Designed to provide exceptionally talented researchers with the mentoring and hands-on experience required to prepare them for careers as independent scientists What makes life work? Molecular and Cell Biology, Cell Dynamics, Stem Cells and Developmental Biology; Laboratory Rotation; Thesis Laboratory. www.h-ka.de. In her current role, she leads a small team of analysts within the core, helping set directions on analysis, guide communication, troubleshoot problems, and identify how to best handle new or complex data types. Hes developing computational frameworks to help design and analyze his collaborators CRISPR-based experiments as well as large genetic data sets from patients. The proteins Njomen studies are involved in recycling cellular waste and debris, a process known as autophagy, which also plays a central role in the immune systems control of pathogens. A better grasp of the basics could help scientists understand why such mishaps are common in neurodegenerative diseases like Alzheimers and Parkinsons. Such interference may ultimately lead to new ways to stop deadly infections. Systems Biology, Evolution and Model Systems; Laboratory Rotation; Thesis Laboratory. Work closely with your care team or main doctor. Faculty of Engineering. His findings could help researchers devise ways to repair or replace damaged tissues by directing cells into specific differentiation paths. Quinton Smith wants to engineer stem cell-derived mini livers in the lab. Wint has served on the executive board of many organizations, held a position in the Center for Inclusive Education, and has advocated for graduate students on local, state, and national levels. Nicolle Rosa Mercado studies how mRNA dynamics impact the regulation of protein production upon cellular stress. At Stowers, he extended his exploration of the molecular details influencing the cellular and organismal diversity. DNA condensed in the nucleus is strategically packed so that genes can be turned on and off at the right times. Arielle Woznica wants to know what happens when choanoflagellates get sick. Her research could lead to new therapies for restoring touch in people with nervous system disorders or injuries. Welcome! Marissa Scavuzzo studies the nervous system the one inside your gut. He is an Investigator and faculty member for the graduate school in addition to co-leading the Cancer Biology initiative at the University of Kansas Cancer Center. To address this long-standing problem of biology, Snchez Alvarado and his team use the planarian Schmidtea mediterraea as a model system. Monique Mendes is working to understand how astrocytes specialized cells of the central nervous system coordinate and respond to neuronal activity across brain states and behavior. Molecular and Cell Biology, Kappel hopes this work will inform future efforts to develop therapeutics for degenerative diseases. This phase of the award has a maximum length of four years. Alejandro joined the Institute in 2011, was named its Scientific Director in 2019, and named Executive Director and Chief Scientific Officer in 2021. Adriane Otopalik wants to know how the male fly brain has evolved to generate distinct courtship sequences across species. Neuroscience, Alejandro Snchez Alvarado, Ph.D., is the President and Chief Scientific Officer of the Stowers Institute. Pursuing innovative, creative research in biology Unprecedented access to leading scientists, state-of-the-art equipment, technical experts, and organizational support Welcome to The Graduate School of the Stowers Institute for Medical Research The Ph.D. The Institute pledged to select up to 25 Hanna Gray Fellows annually for the next decade. She aims to understand how these organisms as well as evolutionarily ancient animals including sponges, comb jellies, and sea anemones sense and respond to viruses. Systems Biology, Evolution and Model Systems; Laboratory Rotation; Thesis laboratory. James Nuez is developing new tools to allow researchers to manipulate the activity of multiple genes simultaneously. Dr. Betty Drees was appointed as the President of The Graduate School of the Stowers Institute for Medical Research in Spring 2018. Jasmin Camacho is studying wild bats using cutting-edge metabolomics to identify and map the metabolic mechanisms that protect against the damaging effects of sugar consumption. As a Graduate Career Coach at Stony Brook University, she led one-on-one career coaching sessions and coordinated career exploration seminars. Hamids studies of the interactions between dopamine-producing neurons and blood vessels could deepen our understanding of how blood hormones influence decision-making and goal-directed behavior. Most research has focused on conserved microproteins, but this excludes rapidly evolving microproteins with potential roles in immunity. Linheng Li, Ph.D., joined the Stowers Institute in 2000 and focuses on stem cell and cancer research. Genetics and Genomics, Tatjana Piotrowski, Ph.D., a developmental biologist, is an Investigator at the Stowers Institute. She then transitioned to a role as a Research Specialist in Microscopy, where she worked with laboratory researchers throughout the Stowers Institute to plan, perform, analyze and publish imaging experiments to address a wide range of biological questions. Using lab-grown organs to mimic the human intestine, Scavuzzo is mapping the diversity of support cells called glia. 1000 E 50TH ST Kansas City MO 64110-2262 Kansas City MO | IRS ruling year: 2005 | EIN: 20-2993509 Organization Mission SIMR'S EXEMPT PURPOSE IS TO PERFORM MEDICAL RESEARCH IN THE PUBLIC INTEREST WITH THE GOAL OF EXPANDING OUR UNDERSTANDING OF THE FUNDAMENTAL PROCESSES OF LIVING CELLS . Sarah E. Smith, Ph.D., is Project Manager for the Office of the Executive Director at the Stowers Institute. Faculty & Staff For general questions about our programs, please visit our department office in PSY-100 or contact us at 562-985-5001. Ardem Patapoutian Investigator . Aaron Joiner is a firm believer that structure dictates function: from items that we can easily see and use (e.g., vehicles, furniture, tools) to cellular components that are challenging to visualize (e.g., DNA, RNA, proteins). Yet, in the battle against cancer, our immune cells can become exhausted and lose their tumor-killing potential. Scientists suspect that small droplets called nuclear condensates help guide this packing process, concentrating important proteins and making sure that related genes stick close together. One family of immune proteins unravels molecular strings that some bacteria use to travel through infected cells. Like octopus and squid, cuttlefish have an amazing ability to change color to camouflage themselves. Stowers Institute for Medical Research 1 year 11 months Graduate Researcher Jun 2022 - Present1 year 2 months Research Scholar Sep 2021 - Jun 202210 months Kansas City, Missouri, United States.
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